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Acknowledgements The authors acknowledge the support of grants from Inserm, CNRS, Universit Paris Cit, Agence Nationale de la Recherche (ANR), Socit Francophone du Diabte (SFD), Fondation pour la Recherche Mdicale (FRM), the Dutch Organization for Scientific Research (ZonMW) and DiabetesFonds

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Furthermore, concentrations of up to 300 mM glucose do not induce GLP-1 secretion from colonic human mucosa because GLP-1 producing L-cells barely express SGLT1 (43, 53, 58, 72)

The FDA does not conduct premarket review for compounded drugs to evaluate their safety, effectiveness, or quality